Livther health after SVR

[Diana66]

Besides what the studies are showing as I believe that sometimes they are presented a bit skewed depending on what the author wants to proove, what is your personal experience (or of people you know of) about liver health after SVR. 6months , 12 months, 1 year, 5 years

Anything !!!  I am coming across so many articles having so many contradictions that I do not know what to believe anymore.

[Diana66]

Any other feedback?

[crossroadsec]

Yeah. I wonder about the compensated thing too. My gastro said he would always consider me decompensated because of ascites, paracentesis and variceal bleed out. The transplant doctor said that it was a term to describe that the liver was not able to carry (maybe compensate?) the burden placed on it. It can no longer filter well?
On the other question, I'm 9 mos SVR. Doing well and still working. I'm tired and fuzzy some days. I've done a couple of 3K's - walking instead of running now due to bleed. I'm training for another one in a month. Slow progress. Maybe due to decompensation? lol. I get achy. yeah. But I'm alive! Thanks for the post. It'll be interesting to watch...
I've an nutritional ninja. It's my lifesaver. NO cheating. Ever. xoxo Karen:)

[rk2761]

This is probably a dumb question, but what do the words compensated and decompensated mean in relation to cirrhosis?

rk

[Diana66]

Thank you Hector

What is "activity Index" ?

[HectorSF]

It all depends on the stage of liver disease before treatment.
In general all people with stages F0, F1, F2, F3, liver disease is totally reversible. For those people most have no symptoms and the liver disease that they do have has no effect of the liver's ability to perform all functions.
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George S, et al. Hepatology. 2008;49:729-738
SVR Associated With Improved Histologic Outcome

150 patients with SVR underwent long-term follow-up

128 patients reached 4-year follow-up, biopsy offered to those with fibrosis ≥ F2

Of 49 patients with paired biopsies, 82% experienced decrease in fibrosis score, 92% decrease in activity index

20% had normal to near-normal histology on follow-up
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While theoretically it is good to have minimal lever disease it actually has no impact on the liver's ability to function or any other body system. It is a myth that people without hepatitis C have no liver disease. The majority older people (50 and up) have some degree of liver disease. The liver also ages along with all other body parts so the liver of a 60 year old is a lot less robust then a 20 year old's liver.

For those with compensated cirrhosis (F4) liver disease is partially reversible. A lot depends on how much portal hypertension the scarring creates. Compensated cirrhosis is only part irreversible. If a cirrhotic has enlarged spleen and varices they will continue to have them after treatment. Which is why they should be monitored periodically after treatment. Also they have an increased risk of liver cancer although it is a lot less than those with active hep C and progressive liver disease.

For those with decompensated cirrhosis and end stage liver disease it is irreversible and will lead to liver failure in time. These people will never a new donor liver to continue living.

Cheers!
Hector

[BoceprevirGal]

I'll be getting my 24 wk post labs this week, so I will keep you posted~