Glucophage and NASH

Posted By Aimee on January 06, 1999 at 09:51:46:







I am a white female age 27.  I am currently about 80 pounds over my "desired" weight.  I have been initially diagnosed with fatty liver, then after a biopsy, with NASH, because of moderate scarring - no cirrhosis yet.  My GI tells me that weight loss is the primary treatment for this disorder.  However, I also have PCOS (poly-cystic Ovarian Syndrome) AKA Stein-Leventhal Syndrome.  This syndrome causes hyperinsulinemia, and hence makes it EXTREMELY difficult to lose weight.  I have since discovered that some endocrinologists are using Glucophage, a drug for diabetics, to decrease insulin resistance, and that many patients w/PCOS who have been unable to lose weight, have been losing it in truckloads.  My questions are:  is Glucophage safe for me to take while I have NASH, keeping in mind it may be what helps me lose weight?  Secondly, because of my PCOS I am having problems getting pregnant.  My GI suggested to me that it might be fatal for me to get pregnant, because of the strain on my liver.  Is that a *real* possibility, or was he trying to scare me into losing weight?
It seems I am in a circle:  I am overweight (partially) because of PCOS, which has cuased liver problems.  In order to treat the PCOS, to alleviate the liver problems, I may only hurt it more!  Plus I'm finding that GI drs know nothing about PCOS and OBGYNs know nothing about NASH!
Any thoughts would be helpful.
Thanks so much for your time.
Aimee :)