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MTHFR Gene Mutation and MS

I am interested to learn if any here diagnosed with MS also have found that they have a gene mutation called MTHFR. It effects how the body processes folate.....and the long term effects are being connected with neurological diseases such as MS.
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Avatar universal
I have a double copy of mthfr gene mutation... A1 & C6.... and have gastroparesis and white matter lesions on the brain
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2094545 tn?1335117731
Several studies have linked the MTHFR A1268C mutation with MS

http://www.mthfrsupport.com.au/condition/ms/

https://www.ncbi.nlm.nih.gov/pubmed/23523621
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Avatar universal
Hi, I am still in limbo with my diagnosis as well. I have however been told that I am homozygous for the mthfr c677t gene. I have been sick since I was 17 years old and I am now 33. I too suffer from severe light headedness and crazy stomach symptoms along with a host of other symptoms. My regular blood tests also come back relatively normal, even if I am bedridden with severe sickness for a week at a time. I am being tested (MRI) in 2 days for signs of Als, Ms or Parkinson's. I know that I have b-12 deficiency and very high homocysteine that can cause severe symptoms in itself. Have u been checked for any gene or metabolic disorders? My advise to u is DON'T STOP looking for an answer! You HAVE got to find a doctor who believes his patients and their symptoms! Until you do, I fear that you will be stuck in this health crisis alone, as I was for MANY, MANY years! I found a great general practitioner who has found my gene mutation and other illnesses on his own. I have seen many specialists with no answers from them whatsoever...talk about being heartbroken after each resultless appointment. My family doctor saved my life and now he is on my side no matter what medical road I go down. Keep looking, there is a doctor who will listen and believe you! And in my opinion YES you could very well be suffering from Ms! Genes make and break us, and are hereditary! I hope you can find some answers. I know my medical search is far from over, but baby steps in the right direction is better than standing still.  Find the right support and fight for your health! Only you know your body. Good luck!!!!!!!!!!!!!
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1 Comments
Please look up methylation. Stay away from folic acid...it's in all of our bread/wheat based foods. It's best to go gluten free. Take only bio available b-12 as in methylcobalamin. Take only methylfolate not folic acid! I don't have MS but it is in my family. High homocystein levels and low b-12 is a sign of these mutated genes. These low cost vitamins do work...I know first hand. Besides natural vitamins won't hurt anyone as long as you stay within the daily allowances. Find a good homeopath that knows about these mutations. It may not cure the disease but you will certainly feel better and that's a good thing in itself.
Avatar universal
Dear anyone who still checks this article I still need help. I'm so very sorry if my illness doesn't seem to be this bit I can't get help anywhere. I had a ton if blood tests and nothing showed. Still having the same symptoms but now lightheadedness comes and goes. Sometimes I seem to have to burp a lot now and my stomach makes growling noises all day. I'm having like body tremors especially in my lower body area. Doctors can't figure out what's wrong with me and my dr doesn't know what to do. I don't have a heart problem and my doctor is calling it a mystery illness. He won't  call me back and said he had no solution. My mother and aunt has MS can it be genetic? Do please help if anybody is still here please help
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5112396 tn?1378017983
There are currently no confirmed bio-markers that occur at 100% correlation with MS. If there were, we'd have that much sought-after unequivocal test for MS.

Evidence-based medicine is constantly searching for such bio-markers. My own tissue and RNA is in three such studies at the moment. Mainstream medicine, I can assure you, is *very* interested in discovering these. But they also demand evidence. We're not there yet.
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9745005 tn?1410044366
Wowsers!  I recently found out I have the MTHFR c677t mutation, still in limbo.  I mentioned it to a Neurologist and he had no clue what I was talking about...and also appeared to give it no thought since a functional nutritionist identified it thru the blood work I had done with her.  Mainstream medicine gives very little credit to "outside the box" care.  Hmmmm...another piece of my puzzle?!

Karen
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Avatar universal
I recently found out that I had a double  mutation of the MTHFR and  was recently diagnosed with MS.
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Avatar universal
I was tested and do have MTHFR gene mutation. info I am reading correlates this with various neurological diseases....I have MS.
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147426 tn?1317265632
The field of genetics is exploding finding genes associated with MS  

According to a fascinating article put out by the Multiple Sclerosis Association of America (MSAA) the strongest risk genetic risk factor yet found is a specific gene - HLA DRB1*1501.  All together roughly 350 genes have been discovered that are "significantly associated" with MS activity.  Interestingly, 155 of these are associated with Vitamin D metabolism.

In 2001 the results of a huge MS genetic study was published in "Nature".  Using 10,000 people with MS and 17,000 controls a global collaboration of scientists identified 29 genetic variants associated with MS. These added to and confirmed prior identified 23 variants.

Thank you for this report on a gene associated with folate metabolism.  It just adds to a body of knowledge that is still looking for real solid info the causes and process of MS.

A genetic component has been suspected for decades and research is backing that up.  Remember that these genes may be associated with the risk of MS, with it's development, with onset, with the form of SM a person has, with the patterns of relapses and possibly with the response to some of the MS meds.

I have not been tested for any of them.

Quix
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667078 tn?1316000935
I have not heard of this mutation myself.


Alex
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