The hole like depressions are likely to be due to scar formation and may not respond to topical/ systemic medications and interventional techniques such as laser etc may be required. You may consider consulting a dermatologist for appropriate management.
Hope this is helpful.
Acne holes are essentially scars caused by prior acne. While acne doesn't generally scar, many individuals pick or squeeze their acne. Wear sunscreen daily. Sun exposure can worsen the appearance of your acne holes. As the sun damages your skin, it weakens its ability to heal from scarring.
My advice is better to take laser treatment to get rid from acne scars.
My advice for you , just try renova retin a cream once..It will really helpful for you..