Hi there! I'm sorry you're struggling, I know it's tough.
I've experienced DR when my panic was severe, and yes, it's awful. It's one of the more upsetting effects of anxiety. Here's a journal I wrote about it...and more helpful even than the journal is all of the comments. You'll see that this is a pretty common occurrence for anxiety sufferers:
http://www.medhelp.org/user_journals/show/11569/Derealization-and-Depersonalization-VERY-common-anxiety-effectsplease-read
Truly, the most effective way to address it is to dismiss and ignore it as much as you can. Yes, I know, easier said than done, but the more you ruminate about it, the more you focus on it, and start avoiding life, the worse it gets, and the longer it sticks around.
Going back to work would be very very helpful for you. Yes, it will stink for a little while, and you'll struggle to concentrate, but the busier you get, and the more you try to return to a normal daily schedule, the more you'll notice that the DR isn't as pronounced.
If you aren't already, get involved with therapy, to help you learn coping skills. Really though, the best way to combat DR is time, patience, and distraction. It will most likely take some time, but if you consistently throw yourself into daily life, with work, exercise, etc.....you will overcome it. It took me probably about 6 months, and literally, it was like one day I realized it wasn't there anymore. As quick as it came, it left. It was tough...I feel for you.
Keep posting, let us know how you're doing, you're NOT alone, that's for sure!