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Is Testicular Atrophy Reversible?

My husband was diagnosed with low Testosterone levels in 2000.  He started on patches and later injections of supplemental testosterone.  Our doctor never did any other hormone testing and his levels were not checked on a regular basis.  We conceived a child in 2003 and she was born in 2004.  Recently we had fertility tests done as we have not been able to have another child.  It was found that he had azoospermia.  He also has a great degree of testicular atrophy.  We are obviously devastated.  My concern is whether or not this can be reversed and if we will ever again be able to have a child.  Should he stop the testosterone?  The whole situation is extremely confusing and frustrating.  I would be grateful of any help/advice you could give.  Is there a light at the end of the tunnel?
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Avatar universal
can you reverse testicular atrophy without completely stopping testosterone therapy?  when I noticed that my testicles were shrinking, I went off androgel (10 g. daily), for four days.  by the end of the four days, they were pretty much back to normal size.  back on treatment, one month later I tried again, but they are taking longer to restore this time.  can you trick your testicles into thinking they need to keep producing, and thus stop shrinking, by cycling in and out of synthetic testosterone treatments? if so, is this safe?  I need the testosterone, but the atrophy is also very distressing.
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MEDICAL PROFESSIONAL
Hi,

Testicular atrophy is a side effect of treatment with testosterone and occurs due to the suppression of the normal hypothalamic-pituitary-gonadal axis.

This side effect is best treated if it has been diagnosed in the early stages. A few treatment options include treatment with human chorionic gonadotropin and cessation of testosterone treatment.

HCG treatment can involve 5000 units in one week or 1000 units every other day and are administered after complete cessation of testosterone supplements.

Do post here for any further doubts in this regard.
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