How are you? Side effects of medroxyprogesterone may include spotting or breakthrough bleeding, changes in menstrual periods; breast tenderness or discharge, mild itching or skin rash;, sleep problems, changes in appetite or weight, and mild stomach pain, bloating, nausea. (ref: http://www.drugs.com/sfx/medroxyprogesterone-side-effects.html) If it persists, it is best that you have this checked by your gynecologist for proper evaluation. Additional diagnostic tests may also be done. Take care and do keep us posted.