BREAST CANCER EXPERT FORUM
ER/PR results

ER/PR results

I  just had a lumpectomy and sentinel node biopsy where the tumor was found to be small (0.7cm), margins clear (nearest margin was the inferior margin at 0.6 cm away; others were 0.9 cm, 1.0 cm, 1.4 cm, 1.5 cm, and 2.4 cm).  The sentinel node was negative.   The type is invasive duct ca, Class II/III, tubule formation 2, nuclear grade 3, mitosis 1; vascular invasion and invasive tumor necrosis were absent, with negative multicentricity and negative multifocality.  DCIS was present (nuclear grade 3) with architecture od cribriform/micropapillary.  EIC status is negative; Primarily DCIS with focal invasion was absent; LCIS was absent.  
ER/PR analysis was done on the original core biopsy. I just spoke with my family doctor's office, as they were the ones to receive the core biospy pathology report and they said that the ER/PR was 0/8 and 0/8.

Could I ask some assistance on the pathology findings and what would likely be offered as treatment options? I am 60 years old, post menopausal and otherwise in excellent health.  I particularly don't know how to interpret ER/PR analysis results as I thought they were usually given in percentages.
Thank you.
Marie
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Dear Marie,  Decisions about adjuvant treatment post surgery are based on several factors including size of tumor, status of lymph nodes, the appearance of the cancer under the microscope, the presence or absence of hormone receptors for estrogen and/or progesterone, as well as HER2 status, the general health of the patient etc.  We can not make specific treatment recommendations for an individual in this forum. We can tell you that antiestrogen treatments are frequently given following surgery for ER/PR-positive breast cancer to reduce the risk of recurrence in the form of metastatic disease. Chemotherapy may add an additional benefit that needs to be weighed against the potential side effects. Her 2 positive tumors generally increase risk to intermediate or high risk which would increase the likelihood of adjuvant chemotherapy being recommended.  Your oncologist will be better able to discuss these options with you once the final pathology results are available.  As you have had lumpectomy, radiation therapy to the breast will also be discussed as part of the treatment of the entire breast.

Regarding your question about the report of your ER/PR analysis these are usually reported as percentages.  You should ask your surgeon to help you interpret the report in context of their lab’s reporting methods.  

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