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er/pr low % levels
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er/pr low % levels

I was diagnosed DCIS high grade with comedo necrosis. I had a lumpectomy followed by radiation.  My DCIS was 9% estrogen receptor positive and 6% progesterone receptor positive.  Would taking tamoxifen be beneficial even with my low % levels or would it make little difference in lowering my chance of a recurrence or new cancer?  
Thanks    
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Dear Carolann644, Pathologists use several techniques to test hormone receptors on tissue, and determine if the breast cancer cells respond, or attach, to estrogen receptors and progesterone receptors on the cell. Breast cancer is termed ER (or PR)-positive if its cells have more than a pre-specified baseline “cutoff” level of hormone receptors - the more a breast cancer responds, the higher its numerical test score. The reverse is also true: breast cancers with test scores at or around the cutoff level are called “weakly” ER (or PR)-positive, and those scoring below the cutoff are called ER (or PR)-negative - meaning that hormones do not stimulate the cancer’s growth.

Over the years the methods of testing for estrogen receptors has changed and most hospitals will have arbitrarily chosen 10% or even 20% (of tumor cells expressing ER or PR) as their cutoff for defining positivity.  

The same type and dose of hormonal therapy is generally used for any breast cancer that is classified as ER-positive, even if it has a “weak” degree of positivity (test results close to the cutoff level).

Decisions about use of tamoxifen in an individual case would need to be made in context of the individual situation - risks vs. benefits.  This is a discussion best had with your oncologist.  
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