Chemotherapy Expert Forum
Genetic Testing
About This Forum:

Welcome to the International Chemotherapy forum. Questions related to lung cancer will be answered by a medical doctor.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
This expert forum is not accepting new questions. Please post your question in one of our medical support communities.
Avatar universal
Genetic Testing
I had a lumpectomy on March 5, 2009. The tumor was 1.8cm.  I am HER2+ with infiltrating ductal cancer.  There was no metastasis and I'm Stage 1.  I had my first chemotherapy treatment (Taxatore & Carboplatin) on April 6, 2009 and had a toxic reaction that landed me in the hospital for 11 days.  I almost died.

My questions are this:

1.  Am I a candidate for genetic testing to determine if I really don't need chemotherapy?  If so, where in the Baltimore metropolitan area can it be done?  I return to the oncologist on March 27, 2009 and I want to be totally prepared discuss my options.
2.  If I am not a candidate for genetic testing, can you recommend more conservative preventative chemotherapy drugs that will be effective, preventative and do the job without half killing me?
Discussion is closed
Cancel
1 Answers
Page 1 of 1
322973 tn?1239908038
Hi,

You have an early stage breast cancer (T1N0M0). Also, you are Her2neu positive, and have not provided details of your ER and PR status.

According to the latest NCCN (National Comprehensive Cancer Network) guidelines, any tumor larger than 1 cm requires adjuvant chemotherapy.

As to the question of genetic testing, please let me know your hormone status (ER, PR), so that we can discuss if you qualify for the Oncotype DX test. Also, please mention if you are pre-menopausal or post-menopausal.

The webpage http://www.oncotypedx.com/HealthcareProfessional/Index.aspx?Sid=19 states that:

"The Oncotype DX® assay provides an individualized assessment of the magnitude of chemotherapy benefit and the likelihood of distant recurrence to inform adjuvant treatment decisions. Women with node-negative, estrogen-receptor-positive invasive breast cancer, and post-menopausal women with node-positive, hormone-receptor-positive invasive breast cancer are eligible."

All the best, and God Bless!
Discussion is closed
Cancel
Comment
A
A
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1463449675
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank