Negative Herpes Tests? still have symptoms

HI all

I have been having "issues" including severe itching, pain, burning, occasional fissures - mostly in the perineum/anal area for 2.5.  I always had sensitive skin and pain and burning but the fissures and itching came on strong 2.5 years ago.  At this time I was coming off of anti depressents and neurontin prescribed for the original vaginal pain.  I was tested for STDs including Herpeselct blood test 1 year after the fissures/ itching began.  I was negative HSV 1  - .08 and neg. HSV 2 - .06.  Consistant with my results in the past.  Also, upon visual inspection one dr did a culture just to rule it out - also negative.  Another assured me that it was not herpes and with the tests she was completely sure.  My question is - what else can cause reccurring fissures/ red itchy spots/ cracks with intense itching?  It seems to come on really bad when Im stressed where one fissure is healing and Im already itching intensely again.  Maybe my itching is creating the red cracked skin - should I look for causes of itching?  This is driving me into a depression.  The cracks burn, bleed slightly.  I guess Im asking - with these symptoms can I be confident in my negative tests.  Ive had at least 3 over the past 6 years, always negative for both, but only the 1 tests since the fissures.  I have lost all faith in dr's and sometimes I feel like I know more than them.  Any insight is greatly appreciated, Im driving myself nuts.  BTW  - I also get bad eczema on my mouth/ face/ hands, that also comes on with stress..so maybe thats it?  And - I know nuerontin helps with Vulvodynia - could that cause a similar pain more in the perineum area?

Thank you!

[costincostin]

Hi you all, We are from Bucharest , Romania an d we need a point of view from you. This is my wife story:

I'm 35 years old and i'm 13weeks pregnant. in week 10 an 6 days i meke my first eco(for bi-test).
The result was a cystic hydroma and nucal translucency of 5.6mm. After two days i make another eco to another doctor
and the result was 3.57mm. Then at 11w and 5days another eco with a difrent doctor, result -2.3mm. After 3days first doctor
call me for a new eco and the result was 4.5mm. I've done the carial biopsy and the 48 hours answer did not detect any
abnormal results for cromozons 13,18,21 ( Down rate was 1:114) .In week 12 and 5days i try a difrent doc who measure
the nucal fold between 2.4- 3.00 mm and will call me again after 2weeks( for brain and heart measurements). Also all the doctors
says that the baby is fine , all the parameters are ok( nasal bone , stomach, spine ... all). If you want can also sent the
values. What do you think? For more info contact my husband mail ***@****