What would be reason for enlarged uvula. My husband occasionally has this happen and Sunday morning he could barely swallow as it was the size of a small finger. It is large to begin with, but this happens on occasion.
Recurrent swelling of the uvula can be on an allergic or non-allergic basis. There are some people who are allergic to foods or medications and this is one of the reactions that they experience. Others have a non-allergic reaction to unknown stimuli, which have the same result. In either case, this can be a life-threatening reaction and requires immediate attention. I would recommend that your husband see his physician soon to discuss this situation. In some cases having epinephrine to inject will save that person's life.