Failed Triple Therapy (Peg, Riba, Inc) after 4 Weeks

[Eki1]

You have been very helpful to me, and had asked to be updated on my latest tests.  I had a viral breakthrough at my four week test.  What do I do now?  What do I do with all these extra drugs I have?  What trials should I research?  I was treatment naive and I'm genotype 1A.  Thanks, guys.  I appreciate all you've done for me.

Here are my test results:

Component Hepatitis C RNA Quant
Standard Range
2/22/2012 7075261 A
4/20/2012 90 A
4/27/2012 139 A
5/10/2012 1986 A



Component Standard Range 2/22/2012 4/20/2012 4/27/2012 5/10/2012
WBC 4.0-10.0 1000/mm3 5.0 5.1 4.4 2.9 L
RBC 4.60-6.10 mill/mm3 5.03 4.89 4.65 3.88 L
Hgb 13.7-17.5 gm/dL 15.2 14.8 14.1 11.8 L
Hct 40.0-50.0 % 43.5 42.7 40.5 35.0 L
MCV 79.0-95.0 um3 86.5 87.3 87.1 90.2
MCH 26.0-32.0 pgm 30.2 30.3 30.3 30.4
MCHC 32.0-36.0 % 34.9 34.7 34.8 33.7
RDW 12.0-14.0 % 12.7 13.2 13.2 13.9
MPV 9.4-12.4 fL 10.4 10.3 10.2 10.5
Plt Count 140-370 1000/mm3 158 122 L 129 L 125 L
Segs 34-71 % 67 72 H 66 75 H
Lymphocytes 19-53 % 25 18 L 24 16 L
Monocytes 5-12 % 6 8 7 8
Abs Neutrophils 1.6-7.0 1000/mm3 3.4 3.7 2.9 2.2
Abs Lymphs 0.8-3.1 1000/mm3 1.3 0.9 1.0 0.5 L
Abs Monos 0.2-0.8 1000/mm3 0.3 0.4 0.3 0.2
Imm Gran % 0-1 % 1 1
Diff Type Automated Automated Automated Automated


Component Standard Range 2/22/2012 4/20/2012 4/27/2012 5/10/2012
Glucose 70-115 mg/dL 70 78 82 94
Bun 6-20 mg/dL 10 12 15 11
Creatinine 0.67-1.17 mg/dL 0.72 0.84 0.84 0.99
Sodium 136-145 mmol/L 137 139 142 143
Potassium 3.5-5.1 mmol/L 4.0 3.9 4.0 4.1
Chloride 98-107 mmol/L 100 101 105 105
Bicarbonate 22-29 mmol/L 26 28 28 27
Calcium 8.6-10.5 mg/dL 8.7 8.5 L 9.5 8.5 L
Total Protein 6.0-8.0 g/dL 7.2 7.1 7.5 7.3
Albumin 3.5-5.2 g/dL 4.5 4.4 4.5 4.5
Bilirubin, Tot <1.2 mg/dL 0.8 2.4 H 1.8 H 1.3 H
AST (SGOT) 0-40 U/L 36 29 23 22
ALT (SGPT) 0-41 U/L 48 H 29 17 18
Alkaline Phos 40-129 U/L 82 83 87 90

[frijole]

Boy, I am disheartened to read this.  I so hope all treatment naive patients will clear and never have to do this again.  Did you take Incevik?  

You are a null responder as can-do said since you never cleared.  Maybe they are calling it a breakthrough because your vl increased each testing.  Your test results from 4/20 -- was that week 1? -- were so promising - from 7 million to 90, it is hard to believe this didn't work out.  Were you 100% compliant?  Did you get a biopsy before you treated?

Sorry for all the questions, but I would like to add you to our spreadsheet (go to my profile and click on the pictures).  I think it is important to see all of the results -- not only the successes.

I wish you better luck with a trial -- sorry I cannot give you any information with regards to them.

frijole

[Eki1]

Hi Stormy!

Always nice to hear from you.  I'm going to take my leftover drugs to my doctor on Friday.  I agree that my liver is fine right now, and I can wait for future treatments.  Thanks for this!

Ike

[Eki1]

Thank you, Laura!

[Eki1]

I just looked it up.  It looks really promising.  Here's more information:

http://seekingalpha.com/article/515701-gilead-s-hepatitis-c-drug-poised-to-reach-the-market-as-one-of-the-first-all-oral-combinations

Thanks so much, James!

[Ironpony]

I am so sorry to hear this...I agree that asking about a trial may be worth it. If that is not offered to you then take care of yourself, it will not be long hopefully before these new treatments are offered to everyone.

Stay strong buddy

Best wishes,
Laura