Failed Triple Therapy (Peg, Riba, Inc) after 4 Weeks

[Eki1]

You have been very helpful to me, and had asked to be updated on my latest tests.  I had a viral breakthrough at my four week test.  What do I do now?  What do I do with all these extra drugs I have?  What trials should I research?  I was treatment naive and I'm genotype 1A.  Thanks, guys.  I appreciate all you've done for me.

Here are my test results:

Component Hepatitis C RNA Quant
Standard Range
2/22/2012 7075261 A
4/20/2012 90 A
4/27/2012 139 A
5/10/2012 1986 A



Component Standard Range 2/22/2012 4/20/2012 4/27/2012 5/10/2012
WBC 4.0-10.0 1000/mm3 5.0 5.1 4.4 2.9 L
RBC 4.60-6.10 mill/mm3 5.03 4.89 4.65 3.88 L
Hgb 13.7-17.5 gm/dL 15.2 14.8 14.1 11.8 L
Hct 40.0-50.0 % 43.5 42.7 40.5 35.0 L
MCV 79.0-95.0 um3 86.5 87.3 87.1 90.2
MCH 26.0-32.0 pgm 30.2 30.3 30.3 30.4
MCHC 32.0-36.0 % 34.9 34.7 34.8 33.7
RDW 12.0-14.0 % 12.7 13.2 13.2 13.9
MPV 9.4-12.4 fL 10.4 10.3 10.2 10.5
Plt Count 140-370 1000/mm3 158 122 L 129 L 125 L
Segs 34-71 % 67 72 H 66 75 H
Lymphocytes 19-53 % 25 18 L 24 16 L
Monocytes 5-12 % 6 8 7 8
Abs Neutrophils 1.6-7.0 1000/mm3 3.4 3.7 2.9 2.2
Abs Lymphs 0.8-3.1 1000/mm3 1.3 0.9 1.0 0.5 L
Abs Monos 0.2-0.8 1000/mm3 0.3 0.4 0.3 0.2
Imm Gran % 0-1 % 1 1
Diff Type Automated Automated Automated Automated


Component Standard Range 2/22/2012 4/20/2012 4/27/2012 5/10/2012
Glucose 70-115 mg/dL 70 78 82 94
Bun 6-20 mg/dL 10 12 15 11
Creatinine 0.67-1.17 mg/dL 0.72 0.84 0.84 0.99
Sodium 136-145 mmol/L 137 139 142 143
Potassium 3.5-5.1 mmol/L 4.0 3.9 4.0 4.1
Chloride 98-107 mmol/L 100 101 105 105
Bicarbonate 22-29 mmol/L 26 28 28 27
Calcium 8.6-10.5 mg/dL 8.7 8.5 L 9.5 8.5 L
Total Protein 6.0-8.0 g/dL 7.2 7.1 7.5 7.3
Albumin 3.5-5.2 g/dL 4.5 4.4 4.5 4.5
Bilirubin, Tot <1.2 mg/dL 0.8 2.4 H 1.8 H 1.3 H
AST (SGOT) 0-40 U/L 36 29 23 22
ALT (SGPT) 0-41 U/L 48 H 29 17 18
Alkaline Phos 40-129 U/L 82 83 87 90

[libzo2]

Please forgive my stupid assumption that you had two geno types at once.  Thank you for correcting me.  HCV and Hemophilia are almost on the same current for me - sort of - I have serious clotting problems at times.  TMI here but when I had a menses it was so bad I would regularly be anemic and had great difficulty with the copious amounts.  I have always had a suspicion that my HCV had something to do with this.  I am not an expert but I sense correlations and you have spurred me to do some research.  

I feel you are just getting the stones out of your path to health realizing what will work on the way.  California is so progressive - I would hit the University Hospitals because of the challenge you would represent for them.  They might really appreciate having you as a patient.  Yikes.

You are an inspiration.

[flcyclist]

That I was infected twice with two different genotypes?
------------------------------------------------------------------------------
It appears to me you only have one Geno -1A.   I agree with Pooh.

Sorry to hear about the failed tx and good luck finding a trial for your next step.

[stormy456]

I'm so sorry to hear this news, I can't imagine your disappointment.  What were your most recent biopsy results?  Your liver enzymes look really good, perhaps the damage is not so bad that you need to be in a rush to treat.  There are some very promising new treatments a few years out.   A clinical trial is also a good suggestion, what is your doctor's advice?

With regard to your leftover drugs, we've given anything we had left over to our doctor (also in SD, BTW.)  There are many people that are uninsured and could desperately use them.  

[pooh55811]

First, I am very sorry to hear that the triple med treatment did not work for you. I know it has to be very, very disappointing and disheartening.The drugs, even the triple treatment, just do not work for everyone.

I agree with the others about what can be done in the future (trials, new drugs).

I do not see anywhere in your profile or your posts that you have two Genotypes. All I see is that you are Genotype 1 A. That is only 1 Genotype.

Eki, keep us posted and let us know how things work out in the future and if you start new treatment. People here do care.

Best of luck.

[Eki1]

Also, thank you for the very kind words of encouragement.  I teared up while reading it aloud to my girlfriend.

[Eki1]

Is that what this means?  That I was infected twice with two different genotypes?

Thanks so much for the responses!