Failed Triple Therapy (Peg, Riba, Inc) after 4 Weeks

[Eki1]

You have been very helpful to me, and had asked to be updated on my latest tests.  I had a viral breakthrough at my four week test.  What do I do now?  What do I do with all these extra drugs I have?  What trials should I research?  I was treatment naive and I'm genotype 1A.  Thanks, guys.  I appreciate all you've done for me.

Here are my test results:

Component Hepatitis C RNA Quant
Standard Range
2/22/2012 7075261 A
4/20/2012 90 A
4/27/2012 139 A
5/10/2012 1986 A



Component Standard Range 2/22/2012 4/20/2012 4/27/2012 5/10/2012
WBC 4.0-10.0 1000/mm3 5.0 5.1 4.4 2.9 L
RBC 4.60-6.10 mill/mm3 5.03 4.89 4.65 3.88 L
Hgb 13.7-17.5 gm/dL 15.2 14.8 14.1 11.8 L
Hct 40.0-50.0 % 43.5 42.7 40.5 35.0 L
MCV 79.0-95.0 um3 86.5 87.3 87.1 90.2
MCH 26.0-32.0 pgm 30.2 30.3 30.3 30.4
MCHC 32.0-36.0 % 34.9 34.7 34.8 33.7
RDW 12.0-14.0 % 12.7 13.2 13.2 13.9
MPV 9.4-12.4 fL 10.4 10.3 10.2 10.5
Plt Count 140-370 1000/mm3 158 122 L 129 L 125 L
Segs 34-71 % 67 72 H 66 75 H
Lymphocytes 19-53 % 25 18 L 24 16 L
Monocytes 5-12 % 6 8 7 8
Abs Neutrophils 1.6-7.0 1000/mm3 3.4 3.7 2.9 2.2
Abs Lymphs 0.8-3.1 1000/mm3 1.3 0.9 1.0 0.5 L
Abs Monos 0.2-0.8 1000/mm3 0.3 0.4 0.3 0.2
Imm Gran % 0-1 % 1 1
Diff Type Automated Automated Automated Automated


Component Standard Range 2/22/2012 4/20/2012 4/27/2012 5/10/2012
Glucose 70-115 mg/dL 70 78 82 94
Bun 6-20 mg/dL 10 12 15 11
Creatinine 0.67-1.17 mg/dL 0.72 0.84 0.84 0.99
Sodium 136-145 mmol/L 137 139 142 143
Potassium 3.5-5.1 mmol/L 4.0 3.9 4.0 4.1
Chloride 98-107 mmol/L 100 101 105 105
Bicarbonate 22-29 mmol/L 26 28 28 27
Calcium 8.6-10.5 mg/dL 8.7 8.5 L 9.5 8.5 L
Total Protein 6.0-8.0 g/dL 7.2 7.1 7.5 7.3
Albumin 3.5-5.2 g/dL 4.5 4.4 4.5 4.5
Bilirubin, Tot <1.2 mg/dL 0.8 2.4 H 1.8 H 1.3 H
AST (SGOT) 0-40 U/L 36 29 23 22
ALT (SGPT) 0-41 U/L 48 H 29 17 18
Alkaline Phos 40-129 U/L 82 83 87 90

[libzo2]

Thank you for returning with this unbelievable news.  Your smile is so bright.  One would never know the silent burdon you carry.  I am so sorry for this set back but I want to commend you for your valiant efforts.  Your family must be very proud of you for diving into the unknown.  

I hope some one who is in your particular boat will pop in.  We have a few double geno's.  The most important thing is not to give up.  I am sure you sent those virons running crazy.  I would recommend clinicaltrials.gov.  That's how I found my first attempt because I had no $.  Please let us know what avenues you have considered?  

[willbb]

Oh I am sorry Eki..I read your profile incorrectly about the HIV. My apologies on that..

Try to invesigate getting into a trial as mentioned and please let us know how things are going..
Will

[Eki1]

Hi Will,

Co-infected?  I'm not sure what that means, but I do not have HIV.  I'm a hemophiliac and I only have HCV.  

Ike

[willbb]

Hi Eki.

I am sorry to hear this.. I also failed an attempt and can relate somewhat with the disappointment you must feel.

I see from your profile you are co-infected and this is a comorbidity  that can have somewhat harder to treat results on the HCV.

With all the research being done currently ,in time there will be even more efficient medications available and certainly more options for the co-infected  and  for people that have had a less than stellar result with the ones available today.
As cando mentioned you may want to investigate entering a trial and discussing this with your physician.

My best wishes to you..
Will

[can-do-man]

Its looks as though you never became Und? If so you are a null responder. There are trials going on now without interferon you might ask your doctor about. As for those extra drugs, your doctor should take them, they could be very helpful to somebody.

Sorry about your news, don't give up hope though. Best to you.