Failed Triple Therapy (Peg, Riba, Inc) after 4 Weeks

[Eki1]

You have been very helpful to me, and had asked to be updated on my latest tests.  I had a viral breakthrough at my four week test.  What do I do now?  What do I do with all these extra drugs I have?  What trials should I research?  I was treatment naive and I'm genotype 1A.  Thanks, guys.  I appreciate all you've done for me.

Here are my test results:

Component Hepatitis C RNA Quant
Standard Range
2/22/2012 7075261 A
4/20/2012 90 A
4/27/2012 139 A
5/10/2012 1986 A



Component Standard Range 2/22/2012 4/20/2012 4/27/2012 5/10/2012
WBC 4.0-10.0 1000/mm3 5.0 5.1 4.4 2.9 L
RBC 4.60-6.10 mill/mm3 5.03 4.89 4.65 3.88 L
Hgb 13.7-17.5 gm/dL 15.2 14.8 14.1 11.8 L
Hct 40.0-50.0 % 43.5 42.7 40.5 35.0 L
MCV 79.0-95.0 um3 86.5 87.3 87.1 90.2
MCH 26.0-32.0 pgm 30.2 30.3 30.3 30.4
MCHC 32.0-36.0 % 34.9 34.7 34.8 33.7
RDW 12.0-14.0 % 12.7 13.2 13.2 13.9
MPV 9.4-12.4 fL 10.4 10.3 10.2 10.5
Plt Count 140-370 1000/mm3 158 122 L 129 L 125 L
Segs 34-71 % 67 72 H 66 75 H
Lymphocytes 19-53 % 25 18 L 24 16 L
Monocytes 5-12 % 6 8 7 8
Abs Neutrophils 1.6-7.0 1000/mm3 3.4 3.7 2.9 2.2
Abs Lymphs 0.8-3.1 1000/mm3 1.3 0.9 1.0 0.5 L
Abs Monos 0.2-0.8 1000/mm3 0.3 0.4 0.3 0.2
Imm Gran % 0-1 % 1 1
Diff Type Automated Automated Automated Automated


Component Standard Range 2/22/2012 4/20/2012 4/27/2012 5/10/2012
Glucose 70-115 mg/dL 70 78 82 94
Bun 6-20 mg/dL 10 12 15 11
Creatinine 0.67-1.17 mg/dL 0.72 0.84 0.84 0.99
Sodium 136-145 mmol/L 137 139 142 143
Potassium 3.5-5.1 mmol/L 4.0 3.9 4.0 4.1
Chloride 98-107 mmol/L 100 101 105 105
Bicarbonate 22-29 mmol/L 26 28 28 27
Calcium 8.6-10.5 mg/dL 8.7 8.5 L 9.5 8.5 L
Total Protein 6.0-8.0 g/dL 7.2 7.1 7.5 7.3
Albumin 3.5-5.2 g/dL 4.5 4.4 4.5 4.5
Bilirubin, Tot <1.2 mg/dL 0.8 2.4 H 1.8 H 1.3 H
AST (SGOT) 0-40 U/L 36 29 23 22
ALT (SGPT) 0-41 U/L 48 H 29 17 18
Alkaline Phos 40-129 U/L 82 83 87 90

[Eki1]

I was just thinking how lucky I am for all of you.  I can't believe I post my test scores and you guys take time out of your day and read those tests and contemplate my options...offer me moral support....send me links to trials....I am very, very grateful.

[Idyllic]

Wow, I am really sorry this didn't work out for you. As others indicated it appears you never quite reached UND. I wonder if that makes you a Null responder rather than treatment niave.

Anyway, you are right, that leaves you with a rather sizable box of Incivek and maybe, what..3/4 a bottle of Riba? Your doctor's office might be able to use the Incivek. I know I had an emergency at the end of treating and I was short something like 42 tablets!!

I agree with the others and hope you hang in there and explore the trials. Don't give up hope as there is something out there or coming down the pike that will help you slay this dragon!

[Eki1]

Thanks, Dave!  It's good to know there are others fighting the same battles.

[hdkash]

Sorry to hear this, I failed my first try as well, but my liver was so badd I stayed on treatment for 10 months to give it a break.
As they said in Galaxy Quest - Never give up, never surrender!

There are more and better coming, one will be right for you!

Dave

[Eki1]

Hi frijole,

Yes, you can add me to your spreadsheet.  I will answer your questions honestly.

Yes, I took Incivek.  Yes, I was 100% compliant.  I never missed a dose.  I was never even really late for a dose.  I took it between 15 minutes before to 15 minutes after I was supposed to, depending on how fast I could eat.

I ate fat like clockwork.   Yes, 4/20 was my week 1 test.  

I got an MRI before treatment, but did not get a biopsy.  They didn't want to biopsy me because of the hemophilia.

I also don't understand why this would happen.  I did everything in my power to kick this thing and I guess the dice just rolled against me.

Ike

[LookingForward12]

So sorry to hear that triple therapy did not work for you. Hoping that you get into one of the trials and can beat this virus once and for all!