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Caught in the middle over cytomel debate

by LMcancersurvivor, Nov 17, 2007 06:52AM
Hi, I am a 26 year old female who was diagnosed with thyroid cancer at 14. The cancer has been in remission for 9 years but now my doctors are disagreeing how to treat my hormone replacement. I have been taking 150mg of synthroid for about 5 years now, and have always felt like I needed something more to help with hypothyroid symptoms. My TSH has always been supressed to 0.1 for the cancer prevention, so that has never been an issue. My primary care physician put me on cytomel 25mg last spring in addition to the synthroid, and I felt much better. Now my new endocrinologist thinks it is a very bad idea for me to be on both and wants me to withdraw from the cytomel. I feel like I need to make this important decision for myself because both of my doctors disagree. I feel that my primary care doctor is more concerned with how I feel day- to- day and the quality of my life, while the endocrinologist wants the numbers to be perfect, and he says my T3 is on the high range. I know my numbers aren't dangerous, and the TSH is optimal.
Here are my questions: Why is it considered bad practice by some doctors to combine synthroid and cytomel? Does it have dangerous long- term effects on patients, or cancer patients in particular? And finally, what is the normal way to take cytomel? Is it meant to be divided and taken half in the morning, half at night? Do these need to be exactly 12 hours apart?
Thank you for your help, I am really in a quandry about this!
Member Comments (1)

by GravesLady, Nov 17, 2007 11:59AM
To: LMcancersurvivor

"Several 2005 studies suggested that although some patients may prefer combination therapy, T3 and T4 together do not work better than T4 alone. Patients might like the combined drugs because they cause more weight loss, or a placebo effect may be involved. It does not appear that combination products offer any advantage....." Dr. Koop

T3 has an extremely short biological life in the body and enters directly into cell metabolism.  T-3 is short lived, about 3/4 hours and  should  be taken at least three times per day,  to give you an even
T-3 boost throughout the day. However it is suggested to take every 4 hours day and night.

T3 is no "magic" pill that will necessarily make you feel better.
We  have T3 in our body so the natural breakdown of T4 into T3 absolutely must occur all the time because the cells use T3 not T4. But the natural breakdown occurs as we need it not when we pop it into our mouth.  
T-4 replacement hormone  sypplement is chemically identical to "natural" thyroid hormone. It works exactly like "natural" thyroid hormone.  Whereas, T-3 is a drug.

Taking T3 in pill form is like swallowing uppers because there's a  immediate rush, and then a quick downer  and it can have serious, adverse health consequences. I heard it referred to as cocaine of thyroid drugs.

Good luck with your decision and health


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