Creatinine is a waste product secreted in the blood. In kidney conditions the kidneys do not filter creatinine from the blood resulting in high creatinine levels. GFR is used to measure how effectively the kidneys filter blood. Altered kidney function, dehydration, acute tubular necrosis, atherosclerosis, high protein diet all can cause high creatinine levels. People who have one kidney such as transplant recipients or kidney donors are more susceptible to the effect of dehydration on creatinine.It has been observed that while on CPAP few people may develop fluid retention and impaired renal function. PEEP may reduce urine output. Fluid retention can be due to decreased renal blood flow. It is important to rule out these causes when evaluating high creatinine levels. Seek medical help. Do write to us again.
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